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Accueil > Pages personnelles > Equipe REMEMBER

Claire Rampon

publié le , mis à jour le

DR2 CNRS, HDR

Equipe REMEMBeR


05 61 55 75 75



Key words :
Learning and Memory / Adult neurogenesis / Alzheimer’s disease


Research interests :
Function of new neurons/ Neurological substrate of the cognitive reserve


Expertise :
Behavior / immunohistology / targeted gene expression / cell morphology analysis


Project :

The mammalian brain continues to produce neurons throughout adult life. This capacity for continued neurogenesis originates from progenitor cells located to brain regions such as the dentate gyrus of the hippocampus. Adult neurogenesis gives rise to functionally integrated neurons which may subserve brain functions. Using complementary behavioral, pharmacological, histological, viral and confocal imaging tools, our goal is to decipher whether and how new granular neurons may contribute to the mechanisms that underlie learning and memory processes in the mammalian brain. In particular, our group is using integrated top-down and bottom-up approaches to study how newborn neurons are recruited into neuronal networks and contribute to the formation of long-lasting spatial memories.

We are also interested in the relationships existing between hippocampal neurogenesis and memory impairment as seen during normal and pathological aging. Indeed, with advancing age, the rate of hippocampal neurogenesis decreases dramatically and might contribute to the cognitive decline that accompanies senescence in animals and humans.

Alzheimer’s disease is the most common cause of dementia in the elderly and is characterized by severe cognitive impairments such as failure to form new memories. Because Alzheimer’s disease is also a neurodegenerative disease, the endogenous reservoir of neural stem cells capable of proliferating may represent an endogenous brain-repair mechanism, the further stimulation of which could have a therapeutic potential. Using transgenic mouse models of Alzheimer’s disease, we examine the putative links between impaired learning and memory, altered plasticity and hippocampal neurogenesis during Alzheimer’s disease. We also investigate how endogenous precursors may be used to compensate for neuronal cell loss in the adult brain.


Publications (*co-authorship) :

2013

  • Krezymon A, Richetin K, Halley H, Roybon L, Lassalle JM, Francès B, Verret L* & Rampon C* Modifications of hippocampal circuits and early disruption of adult neurogenesis in the Tg2576 mouse model of Alzheimer’s disease. PLoS One. 2013 27 ;8(9).
  • Dallérac G., Rampon C. & Doyère V. NCAM function in the adult brain : lessons from mimetic peptides and therapeutic potential. (2013) Neurochem Res., 38(6) : 1163-73.
  • Verret L., Krezymon A., Halley H., Trouche S., Zerwas M., Lazouret M., Lassalle JM & Rampon C. Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice. (2013) Neurobiol of Aging., 34(1) : 211-25.

2011

  • Dallérac G., Zerwas M., Novikova T., Callu D., Leblanc-Veyrac P., Bock E., Berezin V., Rampon C. & Doyère V. The Neural Cell Adhesion Molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo. (2011) Learning and Memory, 18(5) : 306-313.
  • Faure A., Verret L., Bozon B., El Tayara N., Ly M., Kober F., Dhenain M., Rampon C. & Delatour B. Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer’s disease. (2011) Neurobiol of Aging, (32) : 407-18

2010

  • Goodman T., Trouche S., Massou I., Verret L., Zerwas M, Roullet P.* & Rampon C.* Young hippocampal neurons are critical for recent and remote spatial memory in adult mice. (2010) Neuroscience 171(3):769-78.


Selected publications before 2009

  • Trouche S., Bontempi B, Roullet P. & Rampon C. Recruitment of adult-generated neurons into functional hippocampal networks contributes to updating and strengthening of spatial memory. (2009) Proc. Nat. Ac. Sci, USA 106(14):5919-24
  • Communiqué CNRS http://www2.cnrs.fr/presse/communique/1564.htm
  • Verret L., Trouche S., Zerwas M. & Rampon C. Hippocampal neurogenesis during normal and pathological aging. (2007) Psychoneuroendocrinology 32(8) S26-S30
  • Verret L., Jankowsky JL., Xu GM., Borchelt DR. & Rampon C. Alzheimer’s-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis.(2007) J. Neurosci (25):6771-80. Communiqué CNRS http://www2.cnrs.fr/presse/communique/1127.htm
  • Bruel-Jungerman E., Rampon C. & Laroche S. Adult Hippocampal Neurogenesis, Synaptic Plasticity and Memory : Facts and Hypotheses, Reviews in the Neurosciences (2007) 18 (2) : 93-114
  • Bruel-Jungerman E., Davis S., Rampon C. & Laroche S., (2006) Long-term potentiation enhances neurogenesis in the adult dentate gyrus. J. Neurosci. (26):5888 –5893
  • Bruel-Jungerman E., Laroche S. & Rampon C. New neurons in the hippocampus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur. J. Neurosci. (2005), 21, 513-521.
  • Feng R.*, Rampon C.*, Tang Y-P., Shrom D., Jin J., Kyin M., Sopher B., Martin GM., Kim SH., Langdon RB., Sisodia S.S. & Tsien J.Z. Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron. (2001) 32, 911-26.
  • Rampon C., Jiang C.H., Dong H., Tang Y-P., Lockhart D.J., Schultz P.G., Tsien J.Z. & Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc. Nat. Ac. Sci. (2000) 97, 12880-12884.
  • Shimizu E., Tang Y-P., Rampon C. & Tsien J.Z. NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation. Science (2000) 290, 1170-1174.
  • Rampon C.*, Tang Y-P.*, Goodhouse J., Shimizu E., Kyin M. & Tsien J.Z. Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat. Neurosci. (2000) 3, 238-244.
  • Rampon C. & Tsien J.Z. Genetic analysis of learning behavior-induced structural plasticity. Hippocampus (2000) 10, 605-609.
  • Tang Y-P., Shimizu E., Dube G., Rampon C., Keerchner G.A., Zhuo M., Liu G. & Tsien J.Z. Genetic enhancement of learning and memory in mice. Nature (1999) 401, 63-69.
  • Tang, Y-P., Shimizu, E., Rampon C. & Tsien, J.Z. Genetic enhancement of learning and memory in NR2B transgenic mice. Experimental Medicine (1999) 17, 2565-2568.
  • Rampon C., Peyron C., Gervasoni D., Pow D.V., Luppi P.H. & Fort P. Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nucleus : A study combining retrograde tracing with glycine-immunochemistry. Eur. J. Neurosci. (1999) 11, 1058-1066.
  • Rampon C., Luppi P.H., Fort P., Peyron C. & Jouvet M. Distribution of glycine-immmunoreactive cell bodies and fibers in the rat brain. Neuroscience (1996) 75, 737-775.
  • Rampon C., Peyron C., Petit J.M., Fort P., Gervasoni D. & Luppi P.H. Origin of the glycinergic innervation of the rat trigeminal motor nucleus. Neuroreport (1996) 7, 3081-3085.


PhD students :

  • Mécanismes cellulaires et moléculaires de la plasticité neuronale liée à la mémoire : neurogenèse et régulations géniques. Bruel-Jungerman Elodie, Université Paris XI (2006). Co-dir S. Laroche
  • Rôle des nouveaux neurones de l’hippocampe dans la mémoire spatiale à long terme. Trouche Stéphanie, Université Paul Sabatier, Toulouse (2009). Co-dir B. Bontempi
  • -* Altérations cellulaires hippocampiques liées à l’âge et récupération cogntive induite par un enrichissement environnemental chez les souris Tg2576 modèles de la maladie d’Alzheimer. Krezymon Alice, Université Paul Sabatier, Toulouse (2012)
  • Caractérisation multiparamétrique des neurones du hilus du gyrus denté chez la souris. Leclerc Clémence, Université Pierre et Maris Curie, Paris VI (2012). Co-dir T. Gallopin
  • Rôle du cycle cellulaire dans le contrôle de la neurogenèse embryonnaire et chez l’adulte : Fonction et régulation de la phosphatase CDC25B. Escudé Timothé, Université Paul Sabatier, Toulouse (2012). Co-dir : F. Pituello
  • Récupération neurogénique et cognitive dans un modèle murin de la maladie d’Alzheimer. Richetin Kevin, Université Paul Sabatier, Toulouse (2014).
  • Encodage de l’information mnésique par les nouveaux neurones de l’hippocampe. Petsophonsakul Petnoi, Université Paul Sabatier, Toulouse (en cours)